1. Li J, Bonkowski MS, Moniot S, Zhang D, Hubbard BP, Ling AJ, Rajman LA, Qin B, Lou Z, Gorbunova V, Aravind L, Steegborn C, Sinclair DA. A conserved NAD+binding pocket that regulates protein-protein interactions during aging. Science. 2017 Mar 24;355(6331):1312-1317.

Link to abstract (https://www.ncbi.nlm.nih.gov/pubmed/28336669)


  1. Van Meter M, Simon M, Tombline G, May A, Morello TD, Hubbard BP, Bredbenner K, Park R, Sinclair DA, Bohr VA, Gorbunova V, Seluanov A. JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks. Cell Reports. 2016 Sep 6;16(10):2641-2650.

Link to abstract (https://www.ncbi.nlm.nih.gov/pubmed/27568560)


  1. Dai H, Ellis JL, Sinclair DA, Hubbard BP. Synthesis and Assay of SIRT1-Activating Compounds. Methods Enzymol. 2016;574:213-44.

Link to abstract (https://www.ncbi.nlm.nih.gov/pubmed/27423864)


  1. Hubbard BP, Badran AH, Zuris JA, Guilinger JP, Davis KM, Chen L, Tsai SQ, Sander JD, Joung JK, Liu DR. Continuous directed evolution of DNA-binding proteins to improve TALEN specificity. Nature Methods. 2015 Oct;12(10):939-42.

Link to abstract (https://www.ncbi.nlm.nih.gov/pubmed/26258293)


  1. Bhullar KS, Hubbard BP. Lifespan and healthspan extension by resveratrol.

Biochim Biophys Acta. 2015 Jun;1852(6):1209-18.

Link to abstract (https://www.ncbi.nlm.nih.gov/pubmed/25640851)


  1. Hubbard BP, Sinclair DA. Small molecule SIRT1 activators for the treatment of aging and age-related diseases. Trends Pharmacol Sci. 2014 Mar;35(3):146-54.

Link to abstract (https://www.ncbi.nlm.nih.gov/pubmed/24439680)


  1. Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair DA. Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell. 2013 Dec 19;155(7):1624-38.

Link to abstract (https://www.ncbi.nlm.nih.gov/pubmed/24360282)


  1. Hubbard BP, Sinclair DA. Measurement of sirtuin enzyme activity using a substrate-agnostic fluorometric nicotinamide assay. Methods Mol Biol. 2013;1077:167-77.

Link to abstract (https://www.ncbi.nlm.nih.gov/pubmed/24014406)


  1. Hubbard BP, Loh C, Gomes AP, Li J, Lu Q, Doyle TL, Disch JS, Armour SM, Ellis JL, Vlasuk GP, Sinclair DA. Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism. Cell Cycle. 2013 Jul 15;12(14):2233-40.

Link to abstract (https://www.ncbi.nlm.nih.gov/pubmed/23892437)


  1. Biason-Lauber A*, Böni-Schnetzler M*, Hubbard BP*, Bouzakri K*, Brunner A, Cavelti-Weder C, Keller C, Meyer-Böni M, Meier DT, Brorsson C, Timper K, Leibowitz G, Patrignani A, Bruggmann R, Boily G, Zulewski H, Geier A, Cermak JM, Elliott P, Ellis JL, Westphal C, Knobel U, Eloranta JJ, Kerr-Conte J, Pattou F, Konrad D, Matter CM, Fontana A, Rogler G, Schlapbach R, Regairaz C, Carballido JM, Glaser B, McBurney MW, Pociot F, Sinclair DA, Donath MY. Identification of a SIRT1 mutation in a family with type 1 diabetes. Cell Metabolism. 2013 Mar 5;17(3):448-455. *co-first author.

Link to abtract (https://www.ncbi.nlm.nih.gov/pubmed/23473037)


  1. Hubbard BP, Gomes AP, Dai H, Li J, Case AW, Considine T, Riera TV, Lee JE, E SY, Lamming DW, Pentelute BL, Schuman ER, Stevens LA, Ling AJ, Armour SM, Michan S, Zhao H, Jiang Y, Sweitzer SM, Blum CA, Disch JS, Ng PY, Howitz KT, Rolo AP, Hamuro Y, Moss J, Perni RB, Ellis JL, Vlasuk GP, Sinclair DA. Evidence for a common mechanism of SIRT1 regulation by allosteric activators. Science. 2013 Mar 8;339(6124):1216-9.

Link to abstract (https://www.ncbi.nlm.nih.gov/pubmed/23473037)


  1. Han J, Hubbard BP, Lee J, Montagna C, Lee HW, Sinclair DA, Suh Y. Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene. Cell Cycle. 2013 Jan 15;12(2):263-70.

Link to abstract (https://www.ncbi.nlm.nih.gov/pubmed/23255128)


  1. Rascón B, Hubbard BP, Sinclair DA, Amdam GV. The lifespan extension effects of resveratrol are conserved in the honey bee and may be driven by a mechanism related to caloric restriction. Aging. 2012 Jul;4(7):499-508.

Link to abstract (https://www.ncbi.nlm.nih.gov/pubmed/22868943)


  1. Price NL, Gomes AP, Ling AJ, Duarte FV, Martin-Montalvo A, North BJ, Agarwal B, Ye L, Ramadori G, Teodoro JS, Hubbard BP, Varela AT, Davis JG, Varamini B, Hafner A, Moaddel R, Rolo AP, Coppari R, Palmeira CM, de Cabo R, Baur JA, Sinclair DA. SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metabolism. 2012 May 2;15(5):675-90.

Link to abstract (https://www.ncbi.nlm.nih.gov/pubmed/22560220)


  1. Minor RK, Baur JA, Gomes AP, Ward TM, Csiszar A, Mercken EM, Abdelmohsen K, Shin YK, Canto C, Scheibye-Knudsen M, Krawczyk M, Irusta PM, Martín-Montalvo A, Hubbard BP, Zhang Y, Lehrmann E, White AA, Price NL, Swindell WR, Pearson KJ, Becker KG, Bohr VA, Gorospe M, Egan JM, Talan MI, Auwerx J, Westphal CH, Ellis JL, Ungvari Z, Vlasuk GP, Elliott PJ, Sinclair DA, de Cabo R. SRT1720 improves survival and healthspan of obese mice. Scientific Reports. 2011;1:70.

Link to abstract (https://www.ncbi.nlm.nih.gov/pubmed/22355589)


  1. Gomes AP, Duarte FV, Nunes P, Hubbard BP, Teodoro JS, Varela AT, Jones JG, Sinclair DA, Palmeira CM, Rolo AP. Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis. Biochim Biophys Acta. 2012 Feb;1822(2):185-95.

Link to abstract (https://www.ncbi.nlm.nih.gov/pubmed/22027215)


  1. Bernier M, Paul RK, Martin-Montalvo A, Scheibye-Knudsen M, Song S, He HJ, Armour SM, Hubbard BP, Bohr VA, Wang L, Zong Y, Sinclair DA, de Cabo R. Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein. J Biol Chem. 2011 Jun 3;286(22):19270-9.

Link to abstract (https://www.ncbi.nlm.nih.gov/pubmed/21467030)


  1. Dai H, Kustigian L, Carney D, Case A, Considine T, Hubbard BP, Perni RB, Riera TV, Szczepankiewicz B, Vlasuk GP, Stein RL. SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator. J Biol Chem. 2010 Oct 22;285(43):32695-703.

Link to abstract (https://www.ncbi.nlm.nih.gov/pubmed/20702418)


  1. Yang Y, Hubbard BP, Sinclair DA, Tong Q. Characterization of murine SIRT3 transcript variants and corresponding protein products. J Cell Biochem. 2010 Nov 1;111(4):1051-8.

Link to abstract (https://www.ncbi.nlm.nih.gov/pubmed/20677216)


  1. Hubbard B, Kuang W, Moser A, Facey GA, and Detellier C. Structural study of Maya Blue: textural, thermal and solid-state multinuclear magnetic resonance characterization of the palygorskite-indigo and sepiolite-indigo adducts. Clays and Clay Minerals. 2003 51(3), 318-326.

Link to abstract (https://pubs.geoscienceworld.org/ccm/article/51/3/318/48319/?searchresult=1)


Click here for a complete list of Dr. Hubbard’s publications. (https://www.ncbi.nlm.nih.gov/pubmed/?term=Hubbard+bp)

Full-text articles are available for download at ResearchGate (https://www.researchgate.net)